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December 6, 2024

The Impact of Ageing on Fat Tissue

What Changes and Why It Matters

Dr. Lana du Plessis

As individuals age, fat tissue undergoes significant changes that influence energy balance, immune function, and overall health. Understanding these changes provides valuable insights into maintaining well-being and managing age-related health challenges.

Changes in Fat Tissue Over Time

Fat tissue consists of different types, each serving distinct purposes. White fat, which stores energy, tends to increase with age, while brown fat, which burns energy to produce heat, decreases. This shift can result in:

  • Increased difficulty managing body weight
  • A higher likelihood of developing diabetes and cardiovascular diseases
  • Elevated inflammation, which may affect other organs

These changes also have broader implications for vital organs such as the brain and liver, potentially contributing to functional decline.

The Role of Fat Tissue

Healthy fat tissue plays a key role in maintaining balance within the body. It supports immune function, aids in tissue repair, and regulates energy levels. However, ageing diminishes the ability of fat tissue to function optimally. Cells responsible for repairing and maintaining fat tissue lose efficiency, leading to slower regeneration and healing of tissue as well as greater wear and tear of tissue, increasing the risk of chronic health issues.

The Ageing Process and Fat Cells

Several interconnected processes contribute to the decline in fat tissue function as people age:

  • Chronic low-level inflammation: Persistent inflammation, even in the absence of infection, gradually harms tissue.
  • Cellular damage: Accumulated damage to DNA and reduced energy production affect how cells perform.
  • Decline in stem cell activity: These specialized cells, which are essential for repairing and regenerating fat tissue, become less effective.
  • Accumulation of old cells: A build-up of worn-out cells disrupts normal tissue function.


These factors collectively reduce the ability of fat tissue to support the body’s needs, contributing to the development of age-related health issues.

Steps to Support Healthy Ageing

Research continues to explore methods for preserving fat tissue function during the ageing process. Reducing inflammation, supporting cell health, and enhancing the activity of regenerative cells are potential strategies for improving outcomes. While solutions are still under development, maintaining a balanced diet, engaging in regular physical activity, and managing stress can help promote healthier fat tissue function over time.

By recognizing the changes in fat tissue associated with ageing, individuals can take proactive steps to support long-term health and well-being.

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